MTAP anticorps (AA 97-196)

N° du produit ABIN7877264

Cet anticorps Souris Monoclonal détecte spécifiquement MTAP dans WB, ELISA et IHC (p). Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour MTAP anticorps (AA 97-196) (ABIN7877264)

Antigène: MTAP (Methylthioadenosine phosphorylase (MTAP))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MTAP est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: MTAP-1813

Détail du produit anti-MTAP anticorps

Épitope: AA 97-196

Fonction: MTAP Antibody / S-methyl-5'-thioadenosine phosphorylase

Purification: Protein G affinity chromatography

Immunogène: A portion of amino acids 97-196 from the human protein was used as the immunogen for the MTAP antibody.

Isotype: IgG2b, kappa

Information d'application

Indications d'application: Optimal dilution of the MTAP antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store the MTAP antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur MTAP

Antigène: MTAP (Methylthioadenosine phosphorylase (MTAP))

Autre désignation: MTAP

Sujet: Recognizes a protein of 31 kDa, which is identified as MTAP (5'-deoxy-5'-methylthioadenosine phosphorylase). It catalyzes the reversible phosphorolysis of methylthioadenosine, which is important in polyamine metabolism and for the salvage of adenine and methionine. The gene encoding MTAP is linked to the tumor suppressor gene, p16INK4A. Deficient levels of MTAP can occur in cancers primarily through co-deletion of the MTAP gene and the p16INK4A gene. Cells expressing MTAP and possessing adenine salvage pathway activity may be less susceptible to malignancy due to growth-inhibitory actions of agents (e.g. antifolates), whose mechanism of action, in part, involves this de novo purine pathway.

UniProt: Q13126

Pathways: Ribonucleoside Biosynthetic Process, Methionine Biosynthetic Process