Filaggrin anticorps (AA 998-1104) (Biotin)

N° du produit ABIN7877301

L’anticorps anti-Filaggrin Monoclonal Souris est utilisé pour la détection de Filaggrin dans des échantillons de Humain. Il a été validé pour IHC (p).

Aperçu rapide pour Filaggrin anticorps (AA 998-1104) (Biotin) (ABIN7877301)

Antigène: Filaggrin (FLG)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Filaggrin est conjugé à/à la Biotin

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: FLG-1563

Détail du produit anti-Filaggrin anticorps (Biotin)

Épitope: AA 998-1104

Fonction: Filaggrin Antibody

Purification: Protein G affinity chromatography

Immunogène: A portion of amino acids 998-1104 from the human protein was used as the immunogen for the Filaggrin antibody.

Isotype: IgG2b, kappa

Information d'application

Indications d'application: Optimal dilution of the Filaggrin antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 0.1 mg/mL with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store the Filaggrin antibody at 2-8oC (up to one month) or aliquot and store at -20oC (longer term).

Détails sur Filaggrin

Antigène: Filaggrin (FLG)

Autre désignation: Filaggrin

Sujet: Filaggrin is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Active filaggrin is present at a level of the epidermis where keratinocytes are in transition between the live nucleated granular layer and the anucleate cornified layer, suggesting that filaggrin aids in the terminal differentiation process by facilitating apoptotic machinery.

UniProt: P20930

Pathways: Sensory Perception of Sound, Stem Cell Maintenance