OPN5 anticorps (C-Term)

N° du produit ABIN7877440

Cet anticorps anti-OPN5 Polyclonal Lapin (ABIN7877440) détecte spécifiquement OPN5 dans WB, IF et IHC. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour OPN5 anticorps (C-Term) (ABIN7877440)

Antigène: OPN5 (Opsin 5 (OPN5))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp OPN5 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC)

Détail du produit anti-OPN5 anticorps

Épitope: C-Term

Fonction: OPN5 Antibody / Opsin 5 / Neuropsin

Purification: Immunogen affinity purified

Immunogène: A synthetic peptide corresponding to a sequence at the C-terminus of human OPN5 was used as the immunogen for the OPN5 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the OPN5 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the OPN5 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur OPN5

Antigène: OPN5 (Opsin 5 (OPN5))

Autre désignation: OPN5

Sujet: OPN5 antibody detects Opsin-5 (also known as Neuropsin or G protein-coupled receptor 136), a light-sensitive G protein-coupled receptor involved in non-visual photoreception. Encoded by the OPN5 gene on chromosome 6p12.3, this protein belongs to the opsin family of photoreceptive GPCRs that use retinaldehyde chromophores to detect light. Opsin-5 absorbs near-ultraviolet light and activates intracellular signaling via inhibitory G proteins (Gi/Go), modulating circadian rhythms and neuroendocrine responses independent of classical retinal photoreceptors.

OPN5 is expressed in brain regions such as the hypothalamus and preoptic area, as well as in peripheral tissues including retina, cornea, skin, and reproductive organs. It functions as a UV-sensitive photoreceptor regulating local circadian oscillators and hormone secretion. In the eye, OPN5 contributes to light entrainment of retinal and non-retinal cells, while in the skin and reproductive tissues, it influences seasonal and environmental light-dependent physiology. The receptor's activation triggers G protein signaling that modulates cyclic AMP levels, gene expression, and ion channel activity.

The OPN5 antibody is a valuable tool for neurobiology, circadian rhythm, and sensory physiology research. Western blot analysis detects a 40 kilodalton band corresponding to Opsin-5, while immunofluorescence and immunohistochemistry reveal membrane localization in neuronal and epithelial tissues. This antibody supports the study of light-dependent signaling outside the visual system and enables mapping of Opsin-5 expression across tissues.

Dysregulation of OPN5 signaling has been linked to altered circadian rhythms, hormonal imbalances, and impaired photic entrainment. In animal models, OPN5 influences melatonin secretion and reproductive seasonality, connecting environmental lighting cues to endocrine function. The OPN5 antibody facilitates the exploration of these mechanisms by providing specific detection of Opsin-5 in experimental systems. NSJ Bioreagents offers this antibody validated for its applications, ensuring consistent and high-quality performance for light-sensing and circadian biology research.

UniProt: Q6U736