ISR-alpha anticorps (Extracellular)

N° du produit ABIN7877547

L’anticorps anti-ISR-alpha Monoclonal Souris est utilisé pour la détection de ISR-alpha dans des échantillons de Humain. Il a été validé pour ELISA.

Aperçu rapide pour ISR-alpha anticorps (Extracellular) (ABIN7877547)

Antigène: ISR-alpha (Insulin Receptor alpha (ISR-alpha))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ISR-alpha est non-conjugé

Application: ELISA

Classe de qualité: Carrier-free

Clone: INSR-1661

Détail du produit anti-ISR-alpha anticorps

Épitope: Extracellular

Fonction: Insulin Receptor alpha Antibody (azide and preservative free)

Purification: Protein G affinity chromatography

Immunogène: A recombinant fragment from the extracellular domain of human Insulin Receptor alpha was used as the immunogen for this Insulin Receptor alpha antibody.

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal dilution of the Insulin Receptor alpha antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: 4 °C,-20 °C

Stockage commentaire: Store the Insulin Receptor alpha antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur ISR-alpha

Antigène: ISR-alpha (Insulin Receptor alpha (ISR-alpha))

Autre désignation: Insulin Receptor alpha

Sujet: The insulin receptor (INSR) is a heterodimeric protein complex that has an intracellular subunit, which is disulfide-linked to a transmembrane segment. The insulin ligand binds to the INSR and initiates molecular signaling pathways that promote glucose uptake in cells and glycogen synthesis. Insulin binding to INSR induces phosphorylation of intra-cellular tyrosine kinase domains and recruitment of multiple SH2 and SH3 domain-containing intracellular proteins that serve as signaling intermediates for pleiotropic effects of insulin. Type 1 diabetes is an autoimmune condition of the endocrine pancreas that results in destruction of insulin secreting cells and a progressive loss in insulin-sensitive glucose uptake by cells.

UniProt: P06213