ISR-alpha anticorps (Extracellular)

N° du produit ABIN7877548

Cet anticorps anti-ISR-alpha Monoclonal Souris (Clone INSR-1661) (ABIN7877548) détecte spécifiquement ISR-alpha dans ELISA. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour ISR-alpha anticorps (Extracellular) (ABIN7877548)

Antigène: ISR-alpha (Insulin Receptor alpha (ISR-alpha))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ISR-alpha est non-conjugé

Application: ELISA

Clone: INSR-1661

Détail du produit anti-ISR-alpha anticorps

Épitope: Extracellular

Fonction: Insulin Receptor alpha Antibody

Purification: Protein G affinity chromatography

Immunogène: A recombinant fragment from the extracellular domain of human Insulin Receptor alpha was used as the immunogen for this Insulin Receptor alpha antibody.

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal dilution of the Insulin Receptor alpha antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store the Insulin Receptor alpha antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur ISR-alpha

Antigène: ISR-alpha (Insulin Receptor alpha (ISR-alpha))

Autre désignation: Insulin Receptor alpha

Sujet: The insulin receptor (INSR) is a heterodimeric protein complex that has an intracellular subunit, which is disulfide-linked to a transmembrane segment. The insulin ligand binds to the INSR and initiates molecular signaling pathways that promote glucose uptake in cells and glycogen synthesis. Insulin binding to INSR induces phosphorylation of intra-cellular tyrosine kinase domains and recruitment of multiple SH2 and SH3 domain-containing intracellular proteins that serve as signaling intermediates for pleiotropic effects of insulin. Type 1 diabetes is an autoimmune condition of the endocrine pancreas that results in destruction of insulin secreting cells and a progressive loss in insulin-sensitive glucose uptake by cells.

UniProt: P06213