alpha Actinin 4 anticorps (full length)

N° du produit ABIN7877604

L’anticorps anti-alpha Actinin 4 Monoclonal Souris est utilisé pour la détection de alpha Actinin 4 dans des échantillons de Humain. Il a été validé pour IHC (p).

Aperçu rapide pour alpha Actinin 4 anticorps (full length) (ABIN7877604)

Antigène: alpha Actinin 4 (ACTN4) (Actinin, alpha 4 (ACTN4))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp alpha Actinin 4 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Classe de qualité: Carrier-free

Clone: 93

Détail du produit anti-alpha Actinin 4 anticorps

Épitope: full length

Fonction: Alpha Actinin 4 Antibody / ACTN4 (azide and preservative free)

Purification: Protein G affinity chromatography

Immunogène: A recombinant full-length human ACTN4 protein was used as the immunogen for this Alpha Actinin 4 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the Alpha Actinin 4 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: 4 °C,-20 °C

Stockage commentaire: Store the Alpha Actinin 4 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur alpha Actinin 4

Antigène: alpha Actinin 4 (ACTN4) (Actinin, alpha 4 (ACTN4))

Autre désignation: Alpha Actinin 4

Sujet: The spectrin gene family encodes a diverse group of cytoskeletal proteins that include spectrins, dystrophins and -actinins. There are four tissue-specific -actinins, namely -actinin-1, -actinin-2, -actinin-3 and -actinin-4, which are localized to muscle and non-muscle cells, including skeletal, cardiac and smooth muscle cells, as well as within the cytoskeleton. Each -actinin protein contains one Actin-binding domain, two calponin-homology domains, two EF-hand domains and four spectrin repeats, through which they function as bundling proteins that can cross-link F-Actin, thus anchoring Actin to a variety of intracellular structures. Defects in the gene encoding -actinin-4 are the cause of focal segmental glomerulosclerosis 1 (FSGS1), a common renal lesion characterized by decreasing kidney function and, ultimately, renal failure.

UniProt: O43707

Pathways: Proton Transport