BCL11A anticorps (full length)

N° du produit ABIN7877691

L’anticorps anti-BCL11A Monoclonal Souris est utilisé pour la détection de BCL11A dans des échantillons de Humain. Il a été validé pour ELISA, IF et FACS.

Aperçu rapide pour BCL11A anticorps (full length) (ABIN7877691)

Antigène: BCL11A (B-Cell CLL/lymphoma 11A (Zinc Finger Protein) (BCL11A))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp BCL11A est non-conjugé

Application: ELISA, Immunofluorescence (IF), Flow Cytometry (FACS)

Clone: PCRP-BCL11A-1H3

Détail du produit anti-BCL11A anticorps

Épitope: full length

Fonction: B-cell lymphoma/leukemia 11A Antibody / BCL11A

Purification: Protein A/G affinity

Immunogène: Recombinant full-length human protein was used as the immunogen for the B-cell lymphoma/leukemia 11A antibody.

Isotype: IgG1

Information d'application

Indications d'application: Optimal dilution of the B-cell lymphoma/leukemia 11A antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the B-cell lymphoma/leukemia 11A antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur BCL11A

Antigène: BCL11A (B-Cell CLL/lymphoma 11A (Zinc Finger Protein) (BCL11A))

Autre désignation: B-cell lymphoma/leukemia 11A

Sujet: Bcl-11a (CtIP-1, EVI9, B cell chronic lymphocytic leukemia (CLL)/lymphoma 11A) and Bcl-11b (CtIP-2, RIT1, B cell CLL/lymphoma 11B) genes play crucial roles in lymphopoiesis and influence the progression of hematopoietic malignancies. Disruption of the Bcl-11b locus is linked to T cell acute lymphoblastic leukemia, and the loss of heterozygosity in mice results in T cell lymphoma. Bcl-11 proteins are related C2H2 zinc-finger transcription factors that act as transcriptional repressors. Bcl-11b can interact with the metastasis-associated proteins MTA1 and MTA2 through the amino-terminal region. Bcl-11a is essential for postnatal development and normal lymphopoiesis. The Bcl-11a mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with Bcl-6.

UniProt: Q9H165

Pathways: Regulation of Cell Size