Recombinant N-Cadherin anticorps (full length)

N° du produit ABIN7877737

Cet anticorps anti-N-Cadherin Monoclonal Lapin (Clone CDH2-7070R) (ABIN7877737) détecte spécifiquement N-Cadherin dans IHC (p). L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour Recombinant N-Cadherin anticorps (full length) (ABIN7877737)

Antigène: N-Cadherin (CDH2) (Cadherin 2 (CDH2))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp N-Cadherin est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Classe de qualité: Carrier-free

Clone: CDH2-7070R

Détail du produit anti-N-Cadherin anticorps

Épitope: full length

Fonction: Recombinant Cadherin 2 Antibody / CDH2 / N-Cadherin (azide and preservative free)

Purification: Protein A/G affinity

Immunogène: Recombinant full-length human protein was used as the immunogen for the recombinant Cadherin 2 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the recombinant Cadherin 2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: -20 °C

Stockage commentaire: Aliquot the recombinant Cadherin 2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur N-Cadherin

Antigène: N-Cadherin (CDH2) (Cadherin 2 (CDH2))

Autre désignation: Cadherin 2

Sujet: Recognizes a protein of ~140 kDa, identified as N-Cadherin (NCAD), also known as CD325, Cadherin 2 and CDH2. CDH2 is a member of the Cadherin superfamily, and consists of five extracellular repeats, a transmembrane domain and a cytoplasmic domain. CDH2 deficient mice die at day 10 of gestation and embryos display major heart defects and malformed neural tubes and somites. Consistent with this, the protein has been implicated in several aspects of cardiac development including the precardiac mesoderm, establishment of left-right symmetry and cardiac looping morphogenesis. Furthermore, CDH2 is normally involved in inducing cell cycle arrest and its expression is frequently deregulated in cancer cells. Studies have linked N-cadherin to cancer metastasis by showing the aggressive tumor cells had preferentially turned on N-cadherin as opposed to E- or P-cadherin.

UniProt: P19022

Pathways: Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Synaptic Membrane