Recombinant N-Cadherin anticorps (full length)

N° du produit ABIN7877741

Cet anticorps Lapin Monoclonal détecte spécifiquement N-Cadherin dans IHC (p). Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour Recombinant N-Cadherin anticorps (full length) (ABIN7877741)

Antigène: N-Cadherin (CDH2) (Cadherin 2 (CDH2))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp N-Cadherin est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Classe de qualité: Carrier-free

Clone: CDH2-3874R

Détail du produit anti-N-Cadherin anticorps

Épitope: full length

Fonction: Recombinant CDH2 Antibody / N-Cadherin / CD325 (azide and preservative free)

Purification: Protein A affinity chromatography

Immunogène: Recombinant full-length human protein was used as the immunogen for the recombinant CDH2 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the recombinant CDH2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: 4 °C,-20 °C

Stockage commentaire: Store the recombinant CDH2 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur N-Cadherin

Antigène: N-Cadherin (CDH2) (Cadherin 2 (CDH2))

Autre désignation: CDH2

Sujet: Recognizes a protein of ~140 kDa, identified as N-Cadherin (NCAD), also known as CD325 and CDH2. NCAD is a member of the Cadherin superfamily, and consists of five extracellular repeats, a transmembrane domain and a cytoplasmic domain. CD325 deficient mice die at day 10 of gestation and embryos display major heart defects and malformed neural tubes and somites. Consistent with this, CD325 has been implicated in several aspects of cardiac development including the precardiac mesoderm, establishment of left-right symmetry and cardiac looping morphogenesis. Furthermore, CD325 is normally involved in inducing cell cycle arrest and its expression is frequently deregulated in cancer cells.Studies have linked N-cadherin to cancer metastasis by showing the aggressive tumor cells had preferentially turned on N-cadherin as opposed to E- or P-cadherin.

UniProt: P19022

Pathways: Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Synaptic Membrane