Calpastatin anticorps (full length)

N° du produit ABIN7877762

Cet anticorps Souris Monoclonal détecte spécifiquement Calpastatin dans IHC (p). Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour Calpastatin anticorps (full length) (ABIN7877762)

Antigène: Calpastatin (CAST)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Calpastatin est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: CAST-1550

Détail du produit anti-Calpastatin anticorps

Épitope: full length

Fonction: Calpastatin Antibody

Purification: Protein G affinity chromatography

Immunogène: A recombinant full-length human CAST protein was used as the immunogen for this Calpastatin antibody.

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal dilution of the Calpastatin antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store the Calpastatin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur Calpastatin

Antigène: Calpastatin (CAST)

Autre désignation: Calpastatin

Sujet: Calpastatin is an intracellular calcium-dependent protease that cleaves cytoskeletal and sub-membranous proteins. Calpains are non-lysosomal, calcium-activated intracellular cysteine proteases. Calpains mediate specific Ca2+- dependent processes including cell fusion, mitosis and meiosis. Calpains are heterodimers of a small regulatory subunit and one of three large catalytic subunits, designated Calpastatin, Calpain 2 and Calpain p94. Calpastatin regulates Calpain by inhibiting both the proteolytic activity of Calpain and its binding to membranes. Calpastatin exists in two types, tissue type and erythrocyte type, resulting from both alternative splicing and proteolytic processing. Calpastatin co-localizes with human leukocyte antigen-DR (HLA-DR) on activated microglia in the aging brain. Calpain influences the process of spermatogenesis and the events preceding fertilization, such as the acrosome reaction.

UniProt: P20810