Recombinant beta Catenin anticorps (full length)

N° du produit ABIN7877826

L’anticorps anti-beta Catenin Monoclonal Souris est utilisé pour la détection de beta Catenin dans des échantillons de Humain. Il a été validé pour IHC (p).

Aperçu rapide pour Recombinant beta Catenin anticorps (full length) (ABIN7877826)

Antigène: beta Catenin (CATNB) (Catenin, beta (CATNB))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp beta Catenin est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Classe de qualité: Carrier-free

Clone: RCTNNB1-7358

Détail du produit anti-beta Catenin anticorps

Épitope: full length

Fonction: Recombinant Catenin Beta Antibody (azide and preservative free)

Purification: Protein A/G affinity

Immunogène: Recombinant full-length human Beta-Catenin/CTNNB1 protein was used as the immunogen for the recombinant Catenin Beta antibody.

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal dilution of the recombinant Catenin Beta antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: -20 °C

Stockage commentaire: Aliquot the recombinant Catenin Beta antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur beta Catenin

Antigène: beta Catenin (CATNB) (Catenin, beta (CATNB))

Autre désignation: Catenin Beta

Sujet: Beta-catenin associates with the cytoplasmic portion of E-cadherin, which is necessary for the function of E-cadherin as an adhesion molecule. In normal tissues, beta-catenin is localized to the membrane of epithelial cells, consistent with its role in the cell adhesion complex. In breast ductal neoplasia, beta-catenin is usually localized in cellular membranes. However, in lobular neoplasia, a marked redistribution of beta-catenin throughout the cytoplasm results in a diffuse cytoplasmic pattern. Immuno-staining of beta-catenin and E-cadherin is helps in the accurate identification of ductal and lobular neoplasms, including a distinction between low-grade ductal carcinoma in situ (DCIS) and lobular carcinoma. Additionally, some rectal and gastric adenocarcinomas demonstrate diffuse cytoplasmic beta-catenin staining and a lack of membranous staining, mimicking the staining pattern observed with lobular breast carcinomas.

UniProt: P35222

Pathways: Peptide Hormone Metabolism