Recombinant CD5 anticorps (full length)

N° du produit ABIN7877922

L’anticorps anti-CD5 Monoclonal Souris est utilisé pour la détection de CD5 dans des échantillons de Humain. Il a été validé pour WB et IHC (p).

Aperçu rapide pour Recombinant CD5 anticorps (full length) (ABIN7877922)

Antigène: CD5

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD5 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Classe de qualité: Carrier-free

Clone: RC5-6429

Détail du produit anti-CD5 anticorps

Épitope: full length

Fonction: Recombinant CD5 Antibody (azide and preservative free)

Purification: Protein A/G affinity

Immunogène: Recombinant full-length protein corresponding to human CD5 was used as the immunogen for the recombinant CD5 antibody.

Isotype: IgG2a, kappa

Information d'application

Indications d'application: Optimal dilution of the recombinant CD5 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: -20 °C

Stockage commentaire: Aliquot the recombinant CD5 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur CD5

Antigène: CD5

Autre désignation: CD5

Sujet: The CD5 antigen is a transmembrane glycoprotein expressed on the surface of practically all mature human T-cells (about 10 % of CD4+ T-cells being CD5 negative). In immature (CD34+) T-cells, CD5 is weakly expressed, the intensity of expression increasing with maturation. CD5 is also expressed in a small subset of normal human B-cells (20 % of B-cells in the peripheral blood, scattered cells in the lymph node mantle zone). The CD5+ cells are probably involved in B-T interaction and their ligand is CD72 which is expressed on all B cells. It appears that CD5+ B-cells on activation primarily produce IgM. They also produce more autoantibodies than normal CD5 negative B-cells. Thus, the CD5+ B-cell population is expanded in rheumatoid arthritis and systemic lupus erythematosus. The CD5 antibody reacts with CD5 expressed on B and T cells, and may be a useful aid for the classification of B and T-cell malignancies. This includes B-cell chronic lymphoid leukemia (B-CLL), B-cell small lymphocytic lymphoma (B-SLL), mantle cell lymphoma (MCL) and T-cell lymphoma and leukemia.

UniProt: P06127