Chp2 anticorps (full length)

N° du produit ABIN7877978

Cet anticorps Souris Monoclonal détecte spécifiquement Chp2 dans WB et IF. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour Chp2 anticorps (full length) (ABIN7877978)

Antigène: Chp2

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Chp2 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Classe de qualité: Carrier-free

Clone: CPTC-CHP2-1

Détail du produit anti-Chp2 anticorps

Épitope: full length

Fonction: CHP2 Antibody / Calcineurin B homologous protein 2 (azide and preservative free)

Purification: Protein G affinity chromatography

Immunogène: Recombinant human full-length protein was used as the immunogen for the CHP2 antibody.

Isotype: IgG2c, kappa

Information d'application

Indications d'application: Optimal dilution of the CHP2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: 4 °C,-20 °C

Stockage commentaire: Store the CHP2 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur Chp2

Antigène: Chp2

Sujet: CHP2 (calcineurin B homologous protein 2), also known as hepatocellular carcinoma-associated antigen 520, is a 196 amino acid protein that contains 4 EF-hand domains and plays a potential role in transmembrane Na+/H+ exchange. By binding to and activating NHE-1, CHP2 increases the pH and works to protect cells from serum deprivation-induced death. Though not typically detected in normal tissues, CHP2 is highly expressed in malignantly transformed cells and is therefore considered to be a tumor-associated antigen. Ectopic expression of CHP2 promotes proliferation of HEK293 cells and knockdown of CHP2 mRNA in HepG2 cells inhibits cell proliferation. Like calcineurin B, CHP2 can bind to and stimulate phosphatase activity of calcineurin A and activate the calcineurin/NFAT signaling pathway.

UniProt: O43745