CRYAB anticorps (full length)

N° du produit ABIN7878045

L’anticorps anti-CRYAB Monoclonal Souris est utilisé pour la détection de CRYAB dans des échantillons de Humain. Il a été validé pour WB et IHC (p).

Aperçu rapide pour CRYAB anticorps (full length) (ABIN7878045)

Antigène: CRYAB (Crystallin, alpha B (CRYAB))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CRYAB est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Classe de qualité: Carrier-free

Clone: CRYAB-7918

Détail du produit anti-CRYAB anticorps

Épitope: full length

Fonction: Crystallin Alpha B Antibody (azide and preservative free)

Purification: Protein A/G affinity

Immunogène: Recombinant human full-length CRYAB protein was used as the immunogen for the Crystallin Alpha B antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the Crystallin Alpha B antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: -20 °C

Stockage commentaire: Aliquot the Crystallin Alpha B antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur CRYAB

Antigène: CRYAB (Crystallin, alpha B (CRYAB))

Autre désignation: Crystallin Alpha B

Sujet: Crystallins are the major proteins of the vertebrate eye lens, where they maintain the transparency and refractive index of the lens. Crystallins are divided into Alpha, Beta and Gamma families, and the Beta- and Gamma-crystallins also compose a superfamily. Crystallins usually contain seven distinct protein regions, including four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Alpha-crystallins consist of three gene products, AlphaA-, AlphaB- and AlphaC-crystallin, which are members of the small heat shock protein family (HSP 20). Alpha-crystallins act as molecular chaperones by holding denatured proteins in large soluble aggregates. However, unlike other molecular chaperones, Alpha-crystallins do not renature these proteins. Expression of AlphaA-crystallin is restricted to the lens and defects of this gene cause the development of autosomal dominant congenital cataracts (ADCC). The human AlphaB-crystallin gene product is expressed in many tissues, including lens, heart and skeletal muscle. Elevated expression of AlphaB-crystallin is associated with many neurological diseases, and a missense mutation in this gene has co-segregated in a family with a Desmin-related myopathy.

UniProt: P02511