DMC1 anticorps (full length)

N° du produit ABIN7878143

Cet anticorps Souris Monoclonal détecte spécifiquement DMC1 dans WB, IF et IHC (p). Il présente une réactivité avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour DMC1 anticorps (full length) (ABIN7878143)

Antigène: DMC1 (DNA Meiotic Recombinase 1 (DMC1))

Reactivité: Humain, Souris, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp DMC1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 2H12-4

Détail du produit anti-DMC1 anticorps

Épitope: full length

Fonction: DMC1 Antibody

Purification: Protein G affinity chromatography

Immunogène: A recombinant full-length human protein was used as the immunogen for the DMC1 antibody.

Isotype: IgG2a, kappa

Information d'application

Indications d'application: Optimal dilution of the DMC1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store the DMC1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur DMC1

Antigène: DMC1 (DNA Meiotic Recombinase 1 (DMC1))

Autre désignation: DMC1

Sujet: DNA repair proteins are necessary for the maintenance of chromosome integrity and are involved in the elimination of premutagenic lesions from DNA. The DNA repair proteins Rad51 and Rad52 are key components of the doublestrand-break repair (DSBR) pathway. Rad51 is essential for mitotic and meiotic recombination, and its mutation in yeast and mammalian cells results in chromosome loss. Overexpression of Rad52 confers resistance to ionizing radiation and induces homologous intrachromosomal recombination. Rad52 is thought to be involved in an early stage of Rad51-mediated recombination. Additional proteins involved in the pathway include Nibrin and Dmc1 (Meiotic recombination protein DMC1/LIM15 homolog). Nibrin, which complexes with Mre11 and Rad50, is absent in Nijemegen breakage syndrome (NBS) patients. Dmc1 is specifically involved in meiotic recombination. An alternative spliced form of Dmc1, designated Dmc1-D, is deleted for a region between the two motifs involved in nucleotide binding. The alternatively spliced Dmc1-D transcript is detected in both male and female germ cells, indicating that the encoded protein may have a role in mammalian genetic recombination in meiosis.

UniProt: Q14565