Recombinant GSTM3 anticorps (full length)

N° du produit ABIN7878303

L’anticorps anti-GSTM3 Monoclonal Souris est utilisé pour la détection de GSTM3 dans des échantillons de Humain. Il a été validé pour WB et IHC (p).

Aperçu rapide pour Recombinant GSTM3 anticorps (full length) (ABIN7878303)

Antigène: GSTM3 (Glutathione S-Transferase mu 3 (Brain) (GSTM3))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp GSTM3 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RGSTM3-8878

Détail du produit anti-GSTM3 anticorps

Épitope: full length

Fonction: Recombinant GSTM3 Antibody / Glutathione S-Transferase Mu3

Purification: Protein A/G affinity

Immunogène: Recombinant full-length human GSTM3 protein was used as the immunogen for the recombinant GSTM3 antibody.

Isotype: IgG2b, kappa

Information d'application

Indications d'application: Optimal dilution of the recombinant GSTM3 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the recombinant GSTM3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur GSTM3

Antigène: GSTM3 (Glutathione S-Transferase mu 3 (Brain) (GSTM3))

Autre désignation: GSTM3

Sujet: Members of the glutathione S-transferase (GST) family of proteins function in the detoxification of xenobiotics to protect cells against toxicant-induced damage. There are eight families of GST proteins, each of which are composed of proteins that have a variety of functions throughout the cell. The GSTM proteins (GSTM1-GSTM5 in human and GSTM1-GSTM7 in mouse) are members of the mu class of enzymes that conjugate with glutathione and function in the detoxification of carcinogens, environmental toxins and products of oxidative stress. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with an increase in a number of cancers, likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene. GSTM3 protein is selectively expressed in the testis and brain. GSTM3 may also be tumor suppressive in RCC, as low expression has been demonstrated to correlate with RCC risk and poor prognosis in post-op patients.

UniProt: P21266