ATRX anticorps (full length)

N° du produit ABIN7878363

L’anticorps anti-ATRX Monoclonal Souris est utilisé pour la détection de ATRX dans des échantillons de Humain. Il a été validé pour IHC (p).

Aperçu rapide pour ATRX anticorps (full length) (ABIN7878363)

Antigène: ATRX (helicase 2, X-linked (ATRX))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ATRX est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Classe de qualité: Carrier-free

Clone: ATRX-7940

Détail du produit anti-ATRX anticorps

Épitope: full length

Fonction: ATRX Antibody / RAD54 (azide and preservative free)

Purification: Protein A/G affinity

Immunogène: Recombinant full-length human ATRX protein was used as the immunogen for the ATRX antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the ATRX antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: -20 °C

Stockage commentaire: Aliquot the ATRX antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur ATRX

Antigène: ATRX (helicase 2, X-linked (ATRX))

Autre désignation: ATRX

Sujet: ATRX is a member of the Snf2 family of helicase/ATPases, which contribute to the remodeling of the nucelosome structure in an ATP-dependent manner, and facilitate the initiation of transcription and replication. Structurally, ATRX contains a PHD zinc finger motif. ATRX is regulated throughout the cell cycle where it is differentially distributed within the nucleus. During interphase, ATRX predominately associates with the nuclear matrix, while during mitosis, ATRX localizes with condensed chromatin. At the onset of M phase, phosphorylation rapidly induces this redistribution of ATRX to the short arms of human acrocentric chromosomes, where it then specifically complexes with heterochromatin protein 1 to mediate chromosomal segregation. Mutations in the ATRX gene correlate with a high incidence of severe X-linked form of syndromal mental retardation associated with thalassemia or ATRX syndrome .

UniProt: P46100