ATRX anticorps (full length)

N° du produit ABIN7878364

Cet anticorps anti-ATRX Monoclonal Souris (Clone ATRX-7940) (ABIN7878364) détecte spécifiquement ATRX dans IHC (p). L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour ATRX anticorps (full length) (ABIN7878364)

Antigène: ATRX (helicase 2, X-linked (ATRX))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ATRX est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: ATRX-7940

Détail du produit anti-ATRX anticorps

Épitope: full length

Fonction: ATRX Antibody / RAD54

Purification: Protein A/G affinity

Immunogène: Recombinant full-length human ATRX protein was used as the immunogen for the ATRX antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the ATRX antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the ATRX antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur ATRX

Antigène: ATRX (helicase 2, X-linked (ATRX))

Autre désignation: ATRX

Sujet: ATRX is a member of the Snf2 family of helicase/ATPases, which contribute to the remodeling of the nucelosome structure in an ATP-dependent manner, and facilitate the initiation of transcription and replication. Structurally, ATRX contains a PHD zinc finger motif. ATRX is regulated throughout the cell cycle where it is differentially distributed within the nucleus. During interphase, ATRX predominately associates with the nuclear matrix, while during mitosis, ATRX localizes with condensed chromatin. At the onset of M phase, phosphorylation rapidly induces this redistribution of ATRX to the short arms of human acrocentric chromosomes, where it then specifically complexes with heterochromatin protein 1 to mediate chromosomal segregation. Mutations in the ATRX gene correlate with a high incidence of severe X-linked form of syndromal mental retardation associated with thalassemia or ATRX syndrome .

UniProt: P46100