Keratin 10 anticorps (full length)

N° du produit ABIN7878477

L’anticorps anti-Keratin 10 Monoclonal Souris est utilisé pour la détection de Keratin 10 dans des échantillons de Humain. Il a été validé pour IHC (p).

Aperçu rapide pour Keratin 10 anticorps (full length) (ABIN7878477)

Antigène: Keratin 10 (KRT10)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Keratin 10 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: KRT10-6961

Détail du produit anti-Keratin 10 anticorps

Épitope: full length

Fonction: CK10 Antibody / Cytokeratin 10 / KRT10

Purification: Protein A/G affinity

Immunogène: Recombinant full-length human protein was used as the immunogen for the CK10 antibody.

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal dilution of the CK10 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the CK10 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur Keratin 10

Antigène: Keratin 10 (KRT10)

Autre désignation: CK10

Sujet: This mAb recognizes a protein of 56.5 kDa, identified as cytokeratin 10 (CK10). CK10 is expressed in all suprabasal layers of the epidermis. In the epidermis, expression of CK10 strictly parallels the extent of differentiation, it is absent in the basal layer, appears in the first suprabasal layers and increases in concentration towards the granular layer. However, CK10 is rarely detected in early stages of vulvar squamous carcinomas (tumors less than 2 cm, clinical stage I) regardless of the tumor grade. In larger and more advanced tumors (greater than 2 cm, clinical stages II and III), CK10 is detected very frequently. Expression of CK10 is related to maturation of malignant keratinocytes, being preferentially detected in more differentiated parts.

UniProt: P13645