LIM Domain Binding 2 Protein anticorps (full length)

N° du produit ABIN7878537

L’anticorps anti-LIM Domain Binding 2 Protein Monoclonal Souris est utilisé pour la détection de LIM Domain Binding 2 Protein dans des échantillons de Humain. Il a été validé pour IF, IHC (p) et FACS.

Aperçu rapide pour LIM Domain Binding 2 Protein anticorps (full length) (ABIN7878537)

Antigène: LIM Domain Binding 2 Protein (LDB2) (LIM Domain Binding 2 (LDB2))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp LIM Domain Binding 2 Protein est non-conjugé

Application: Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Clone: PCRP-LDB2-1B10

Détail du produit anti-LIM Domain Binding 2 Protein anticorps

Épitope: full length

Fonction: LDB2 Antibody / LIM domain binding 2

Purification: Protein A/G affinity

Immunogène: Recombinant full-length human LDB2 protein was used as the immunogen for the LDB2 antibody.

Isotype: IgG2c, kappa

Information d'application

Indications d'application: Optimal dilution of the LDB2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the LDB2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur LIM Domain Binding 2 Protein

Antigène: LIM Domain Binding 2 Protein (LDB2) (LIM Domain Binding 2 (LDB2))

Autre désignation: LDB2

Sujet: The LIM-only (LMO) proteins, LMO1 and LMO2, are nuclear factors that are characterized by a conserved LIM domain. The LIM domain consists of a cysteine-rich zinc-binding motif that is present in a variety of transcription factors, including the LIM homeobox (LHX) proteins expressed in the central nervous system and involved in cell differentiation. LMO1 and LMO2 are expressed in the adult CNS in a cell type-specific manner, where they are differentially regulated by neuronal activity and are involved in regulating the cellular differentiated phenotype of neurons. LMO2 lacks a specific DNA-binding homeobox domain but rather assembles into transcriptional regulatory complexes to mediate gene expression by interacting with the widely expressed nuclear LIM interactor (NLI). NLI, known also as CLIM-1, and the related protein CLIM-2 facilitate the formation of heteromeric LIM complexes and also enhance the nuclear retention of LIM proteins. LMO2 and the related protein LMO4 are expressed in thymic precursor cells. LMO4 is also expressed in mature T cells, cranial neural crest cells, somite, dorsal limb bud mesenchyme, motor neurons, and Schwann cell progenitors.

UniProt: O43679

Pathways: Stem Cell Maintenance