MED21 anticorps (full length)

N° du produit ABIN7878591

L’anticorps anti-MED21 Monoclonal Souris est utilisé pour la détection de MED21 dans des échantillons de Humain. Il a été validé pour WB, ELISA, IF et FACS.

Aperçu rapide pour MED21 anticorps (full length) (ABIN7878591)

Antigène: MED21 (Mediator Complex Subunit 21 (MED21))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MED21 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Flow Cytometry (FACS)

Clone: PCRP-MED21-4B5

Détail du produit anti-MED21 anticorps

Épitope: full length

Fonction: MED21 Antibody / SRB7

Purification: Protein A/G affinity

Immunogène: Recombinant full-length human MED21 protein was used as the immunogen for the MED21 antibody.

Isotype: IgG1

Information d'application

Indications d'application: Optimal dilution of the MED21 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the MED21 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur MED21

Antigène: MED21 (Mediator Complex Subunit 21 (MED21))

Autre désignation: MED21

Sujet: In mammalian cells, transcription is regulated in part by high molecular weight coactivating complexes that mediate signals between transcriptional activators and RNA polymerase. These complexes include the SMCC (SRB and MED protein cofactor complex), which consists of various subunits that share homology with several components of the yeast transcriptional mediator complexes and including the human proteins Srb7, Med6 (also designated DRIP33) and Med7 (also designated DRIP34). SMCC associates with the RNAPII (RNA polymerase II) holoenzyme through Srb7 and, in turn, enhances gene-specific activation or repression induced by DNA-binding transcription factors. Med6 and Med7, as well as other components of SMCC, associate with co-activator proteins from the TRAP (thyroid hormone receptor-activating protein) complex and DRIP (for vitamin D receptor interacting protein) complex to facilitate steroid receptor dependent transcriptional activation. Additionally, SMCC associates with PC4 (positive cofactor 4) to repress basal transcription independent of RNAPII activity

UniProt: Q13503

Pathways: Stem Cell Maintenance, Regulation of Lipid Metabolism by PPARalpha