MPZ anticorps (full length)

N° du produit ABIN7878682

Cet anticorps anti-MPZ Monoclonal Souris (Clone MPZ-7390) (ABIN7878682) détecte spécifiquement MPZ dans IHC (p). L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour MPZ anticorps (full length) (ABIN7878682)

Antigène: MPZ (Myelin Protein Zero (MPZ))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MPZ est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: MPZ-7390

Détail du produit anti-MPZ anticorps

Épitope: full length

Fonction: MPZ Antibody / Myelin Protein Zero

Purification: Protein A/G affinity

Immunogène: Recombinant full-length human MPZ protein was used as the immunogen for the MPZ antibody.

Isotype: IgG2a, kappa

Information d'application

Indications d'application: Optimal dilution of the MPZ antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the MPZ antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur MPZ

Antigène: MPZ (Myelin Protein Zero (MPZ))

Autre désignation: MPZ

Sujet: Zero, also known as myelin protein zero (MPZ) is a Type 1 integral membrane glycoprotein that mediates adhesion of spiraling wraps of the myelin sheath in order to ensure stable synaptic transmission. Zero protein encompasses approximately 50 % of total protein in the sheath scaffolding in contribution to structural integrity of peripheral myelin. Zero guides the compact myelin wrapping process through glycine zipper packing interface-dependent dimer and tetramer formation. Mutations (e.g. G134R) can abrogate multimer formation, cause demyelinating neuropathies, and are known to contribute to conditions that include Charcot-Marie-Tooth disease. Zero cytoplasmic domain undergoes serine and tyrosine phosphorylation, which appears to be prevalent during peak nerve myelination. Zero transcript is moderate in brain, abundant in thymus and most abundant in white matter of the CNS.

UniProt: P25189