NMI anticorps (full length)

N° du produit ABIN7878700

Cet anticorps anti-NMI Monoclonal Souris (Clone PCRP-NMI-1C1) (ABIN7878700) détecte spécifiquement NMI dans FACS. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour NMI anticorps (full length) (ABIN7878700)

Antigène: NMI (N-Myc (And STAT) Interactor (NMI))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp NMI est non-conjugé

Application: Flow Cytometry (FACS)

Clone: PCRP-NMI-1C1

Détail du produit anti-NMI anticorps

Épitope: full length

Fonction: N-Myc Interactor Antibody / NMI / N-myc and STAT interactor

Purification: Protein A/G affinity

Immunogène: Recombinant full-length human N-Myc Interactor protein was used as the immunogen for the N-Myc Interactor antibody.

Isotype: IgG2b

Information d'application

Indications d'application: Optimal dilution of the N-Myc Interactor antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the N-Myc Interactor antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur NMI

Antigène: NMI (N-Myc (And STAT) Interactor (NMI))

Autre désignation: N-Myc Interactor

Sujet: Nmi (for N-Myc interactor) is an interferon inducible protein that associates with multiple transcription factors, including c-Myc, n-Myc, Max, and c-Fos, which contain bHLH-ZIP, bHLH, or Zip domains. Nmi is ubiquitously expressed at low levels throughout various fetal and adult tissues and at higher levels in myeloid leukemias and cell lines overexpressing c-Myc. In addition to binding Myc proteins, Nmi also associates with the Stat family of transcription factors, where it enhances Stat-dependent transcription. Although Nmi lacks an intrinsic DNA binding or activation domain, Nmi enhances the transcriptional activity of the Stat proteins, in response to cytokine stimulation, by recruiting the Stat1 and Stat5 transcriptional coactivators, CREB-binding protein (CBP) and p300. In vitro studies indicate that Nmi, expressed in conjunction with CBP, enhances the transcriptional responsiveness of Stat5 to IL-2 stimulation five-fold over CBP alone by increasing the affinity of Stat proteins for CBP/p300.

UniProt: Q13287