NRF1 anticorps (full length)

N° du produit ABIN7878725

Cet anticorps Souris Monoclonal détecte spécifiquement NRF1 dans WB et IHC (p). Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour NRF1 anticorps (full length) (ABIN7878725)

Antigène: NRF1 (Nuclear Respiratory Factor 1 (NRF1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp NRF1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: NRF1-2609

Détail du produit anti-NRF1 anticorps

Épitope: full length

Fonction: NRF1 Antibody / Nuclear Respiratory Factor 1

Purification: Protein G affinity chromatography

Immunogène: A recombinant full-length human protein was used as the immunogen for this NRF1 antibody.

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal dilution of the NRF1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store the NRF1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur NRF1

Antigène: NRF1 (Nuclear Respiratory Factor 1 (NRF1))

Autre désignation: NRF1

Sujet: The NF-E2 DNA binding protein is composed of two subunits, p45 and MafK, and it regulates expression of globin genes in developing erythroid cells through interaction with Maf recognition elements (MAREs). A family of NF-E2 related proteins, which are collectively known as the Cap 'n' collar (CNC) family and include Nrf1 (also designated TCF11), Nrf2 and Nrf3, are bZIP transcription factors that heterodimerize with Maf proteins to bind MARE sequences. The Nrf proteins also bind the antioxidant response element (ARE) and are implicated in the regulation of detoxification enzymes and the oxidative stress response. They do so by heterodimerizing with Jun family members (c-Jun, JunB and JunD) to activate gene expression, specifically the detoxifying enzyme, NQO1. Nrf2 is widely expressed and is thought to translocate to the nucleus after treatment with xenobiotics and antioxidants, which stimulate its release from a repressor protein Keap1. Nrf3 is highly expressed in placenta, B cells and monocytes.

UniProt: Q16656

Pathways: Regulation of Lipid Metabolism by PPARalpha