OTX2 anticorps (full length)

N° du produit ABIN7878767

Cet anticorps Souris Monoclonal détecte spécifiquement OTX2 dans ELISA et FACS. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour OTX2 anticorps (full length) (ABIN7878767)

Antigène: OTX2 (Orthodenticle Homeobox 2 (OTX2))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp OTX2 est non-conjugé

Application: ELISA, Flow Cytometry (FACS)

Clone: PCRP-OTX2-1E10

Détail du produit anti-OTX2 anticorps

Épitope: full length

Fonction: OTX2 Antibody / Orthodenticle homolog 2

Purification: Protein A/G affinity

Immunogène: Recombinant human full-length OTX2 protein was used as the immunogen for the OTX2 antibody.

Isotype: IgG1

Information d'application

Indications d'application: Optimal dilution of the OTX2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the OTX2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur OTX2

Antigène: OTX2 (Orthodenticle Homeobox 2 (OTX2))

Autre désignation: OTX2

Sujet: Transcription factors OTX1 and OTX2, two murine homologs of the Drosophila orthodenticle (OTD), show a limited amino acid sequence divergence. OTX1 and OTX2 play an important role during early and later events required for proper brain development in that they are involved in the processes of induction, specification and regionalization of the brain. OTX1 is involved in corticogenesis, sensory organ development and pituitary functions, while OTX2 is necessary earlier in development, for the correct anterior neural plate specification and organization of the primitive streak. OTX2 is also required in the early specification of the neuroectoderm, which is destined to become the fore-midbrain, and both OTX1 and OTX2 co-operate in patterning the developing brain through a dosage-dependent mechanism. A molecular mechanism depending on a precise threshold of OTX proteins is necessary for the correct positioning of the isthmic region and for anterior brain patterning. The genes which encode OTX1 and OTX2 map to human chromosomes 2p13 and 14q22.3, respectively.

UniProt: P32243

Pathways: Dopaminergic Neurogenesis