PMS1 anticorps (full length)

N° du produit ABIN7878820

Cet anticorps anti-PMS1 Monoclonal Souris (Clone PCRP-PMS1-2E11) (ABIN7878820) détecte spécifiquement PMS1 dans ELISA, IF et FACS. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour PMS1 anticorps (full length) (ABIN7878820)

Antigène: PMS1 (PMS1 Postmeiotic Segregation Increased 1 (S. Cerevisiae) (PMS1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PMS1 est non-conjugé

Application: ELISA, Immunofluorescence (IF), Flow Cytometry (FACS)

Clone: PCRP-PMS1-2E11

Détail du produit anti-PMS1 anticorps

Épitope: full length

Fonction: PMS1 Antibody / PMS1 protein homolog 1

Purification: Protein A/G affinity

Immunogène: Recombinant full-length human PMS1 protein was used as the immunogen for the PMS1 antibody.

Isotype: IgG1

Information d'application

Indications d'application: Optimal dilution of the PMS1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the PMS1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur PMS1

Antigène: PMS1 (PMS1 Postmeiotic Segregation Increased 1 (S. Cerevisiae) (PMS1))

Autre désignation: PMS1

Sujet: The finding that mutations in DNA mismatch repair genes are associated with hereditary nonpolyposis colorectal cancer (HNPCC) has resulted in considerable interest in the understanding of the mechanism of DNA mismatch repair. Initially, inherited mutations in the MSH2 and MLH1 homologs of the bacterial DNA mismatch repair genes MutS and MutL were demonstrated at high frequency in HNPCC and were shown to be associated with microsatellite instability. The demonstration that 10 to 45 % of pancreatic, gastric, breast, ovarian and small cell lung cancers also display microsatellite instability has been interpreted to suggest that DNA mismatch repair is not restricted to HNPCC tumors but is a common feature in tumor initiation or progression. Two additional homologs of the prokaryotic MutL gene, designated PMS1 and PMS2, have been identified and shown to be mutated in the germline of HNPCC patients.

UniProt: P54277