PRDM1 anticorps (full length)

N° du produit ABIN7878833

Cet anticorps Souris Monoclonal détecte spécifiquement PRDM1 dans FACS et IF. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour PRDM1 anticorps (full length) (ABIN7878833)

Antigène: PRDM1 (PR Domain Containing 1, with ZNF Domain (PRDM1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PRDM1 est non-conjugé

Application: Flow Cytometry (FACS), Immunofluorescence (IF)

Classe de qualité: Carrier-free

Clone: PCRP-PRDM1-2B9

Détail du produit anti-PRDM1 anticorps

Épitope: full length

Fonction: BLIMP-1 Antibody / PRDM1 (azide and preservative free)

Purification: Protein A/G affinity

Immunogène: Recombinant full-length human protein was used as the immunogen for the BLIMP-1 antibody.

Isotype: IgG2a

Information d'application

Indications d'application: Optimal dilution of the BLIMP-1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: -20 °C

Stockage commentaire: Aliquot the BLIMP-1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur PRDM1

Antigène: PRDM1 (PR Domain Containing 1, with ZNF Domain (PRDM1))

Autre désignation: BLIMP-1

Sujet: The development and differentiation of plasma cells, which are terminally differentiated B-cells, are induced by Blimp-1 (B lymphocyte-induced maturation protein, also designated PRDI-BF1). Blimp-1 is a transcriptional repressor that localizes to the nucleus and is considered a master regulator of terminal B-cell development. Alone, Blimp-1 is sufficient to trigger terminal B-cell differentiation. Blimp-1 upregulates the expression of syndecan-1 and J chain, represses IFN-b gene transcription and associates with HDAC to recruit it to DNA, thereby repressing c-Myc. Blimp-1 is expressed during the late stages of B-cell differentiation in immunoglobulin-secreting plasma cells, as well as in long-lived, bone marrow plasma cells. The expression of Blimp-1 defines a checkpoint beyond which fully activated B cells proceed to the plasma cell stage, whereas immature and partially activated cells are eliminated.

UniProt: O75626

Pathways: Regulation of Muscle Cell Differentiation