PRDM1 anticorps (full length)

N° du produit ABIN7878834

L’anticorps anti-PRDM1 Monoclonal Souris est utilisé pour la détection de PRDM1 dans des échantillons de Humain. Il a été validé pour FACS et IF.

Aperçu rapide pour PRDM1 anticorps (full length) (ABIN7878834)

Antigène: PRDM1 (PR Domain Containing 1, with ZNF Domain (PRDM1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PRDM1 est non-conjugé

Application: Flow Cytometry (FACS), Immunofluorescence (IF)

Clone: PCRP-PRDM1-2B9

Détail du produit anti-PRDM1 anticorps

Épitope: full length

Fonction: BLIMP-1 Antibody / PRDM1

Purification: Protein A/G affinity

Immunogène: Recombinant full-length human protein was used as the immunogen for the BLIMP-1 antibody.

Isotype: IgG2a

Information d'application

Indications d'application: Optimal dilution of the BLIMP-1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the BLIMP-1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur PRDM1

Antigène: PRDM1 (PR Domain Containing 1, with ZNF Domain (PRDM1))

Autre désignation: BLIMP-1

Sujet: The development and differentiation of plasma cells, which are terminally differentiated B-cells, are induced by Blimp-1 (B lymphocyte-induced maturation protein, also designated PRDI-BF1). Blimp-1 is a transcriptional repressor that localizes to the nucleus and is considered a master regulator of terminal B-cell development. Alone, Blimp-1 is sufficient to trigger terminal B-cell differentiation. Blimp-1 upregulates the expression of syndecan-1 and J chain, represses IFN-b gene transcription and associates with HDAC to recruit it to DNA, thereby repressing c-Myc. Blimp-1 is expressed during the late stages of B-cell differentiation in immunoglobulin-secreting plasma cells, as well as in long-lived, bone marrow plasma cells. The expression of Blimp-1 defines a checkpoint beyond which fully activated B cells proceed to the plasma cell stage, whereas immature and partially activated cells are eliminated.

UniProt: O75626

Pathways: Regulation of Muscle Cell Differentiation