QKI anticorps (full length)

N° du produit ABIN7878887

Cet anticorps Souris Monoclonal détecte spécifiquement QKI dans WB, IF, ELISA et FACS. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour QKI anticorps (full length) (ABIN7878887)

Antigène: QKI (Protein Quaking (QKI))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp QKI est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), ELISA, Flow Cytometry (FACS)

Clone: PCRP-QKI-2F10

Détail du produit anti-QKI anticorps

Épitope: full length

Fonction: QKI Antibody / Protein Quaking

Purification: Protein A/G affinity

Immunogène: Recombinant full-length human protein was used as the immunogen for the QKI antibody.

Isotype: IgG2c

Information d'application

Indications d'application: Optimal dilution of the QKI antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the QKI antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur QKI

Antigène: QKI (Protein Quaking (QKI))

Autre désignation: QKI

Sujet: QKI, also known as HKQ, QK, QK3 or quaking, is a 341 amino acid protein that localizes to both the cytoplasm and the nucleus and contains one KH domain. Expressed in the frontal cortex of the brain, QKI functions as an RNA-binding protein that plays an important role in myelinization and specifically binds to the RNA core sequence 5. Additionally, QKI regulates pre-mRNA splicing, and mRNA export and is involved in protecting and promoting the stability of select mRNAs. QKI may be methylated by PRMT1 and may also be phosphorylated at its C-terminus, an event that decreases QKI mRNA-binding affinity. Defects or deletions in the gene encoding QKI are associated with astrocytic tumors and may be involved in the pathogenesis of schizophrenia. Multiple isoforms of QKI exist due to alternative splicing events.

UniProt: Q96PU8