SP100 anticorps (full length)

N° du produit ABIN7879068

L’anticorps anti-SP100 Monoclonal Souris est utilisé pour la détection de SP100 dans des échantillons de Humain. Il a été validé pour WB, ELISA, IP, IF, FACS et IHC (p).

Aperçu rapide pour SP100 anticorps (full length) (ABIN7879068)

Antigène: SP100 (SP100 Nuclear Antigen (SP100))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp SP100 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunoprecipitation (IP), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: PCRP-SP100-1B9

Détail du produit anti-SP100 anticorps

Épitope: full length

Fonction: SP100 Antibody

Purification: Protein A/G affinity

Immunogène: Recombinant full-length human SP100 protein was used as the immunogen for the SP100 antibody.

Isotype: IgG2b

Information d'application

Indications d'application: Optimal dilution of the SP100 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the SP100 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur SP100

Antigène: SP100 (SP100 Nuclear Antigen (SP100))

Autre désignation: SP100

Sujet: The human SP100 gene encodes an autoantigen that co-localizes with PML and NDP52 in distinct nuclear domains, called nuclear dots (NDs) or ND10 nuclear bodies. Papova-, adeno-, and herpesviruses begin their transcription and DNA-replication at NDs, which play a role in autoimmunity, viral infections and in the etiology of acute promyelocytic leukemia. SP-100 is an interferon inducible protein that has two splice variants. One splice variant contains a highly conserved copy of the DNA-binding high mobility group 1 protein sequence, and thus represents a novel HMG-box protein. This alternatively spliced variant of SP-100 has a unique expression and localization pattern that is distinct from the SP-100 full-length protein. The SP100 protein is covalently modified by the small ubiquitin-related protein SUMO-1. SP-100 contains a functional nuclear localization signal and an ND-targeting region, which overlaps with the SP-100 homodimerization domain.

UniProt: P23497

Pathways: Retinoic Acid Receptor Signaling Pathway