SPIC anticorps (full length)

N° du produit ABIN7879074

L’anticorps anti-SPIC Monoclonal Souris est utilisé pour la détection de SPIC dans des échantillons de Humain. Il a été validé pour IF et FACS.

Aperçu rapide pour SPIC anticorps (full length) (ABIN7879074)

Antigène: SPIC (Spi-C Transcription Factor (Spi-1/PU.1 Related) (SPIC))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp SPIC est non-conjugé

Application: Immunofluorescence (IF), Flow Cytometry (FACS)

Clone: PCRP-SPIC-2C5

Détail du produit anti-SPIC anticorps

Épitope: full length

Fonction: SPIC Antibody / Transcription factor Spi-C

Purification: Protein A/G affinity

Immunogène: Recombinant full-length human Transcription factor Spi-C protein was used as the immunogen for the SPIC antibody.

Isotype: IgG2b

Information d'application

Indications d'application: Optimal dilution of the SPIC antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the SPIC antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur SPIC

Antigène: SPIC (Spi-C Transcription Factor (Spi-1/PU.1 Related) (SPIC))

Autre désignation: SPIC

Sujet: The Ets transcription factor family is comprised of DNA-binding proteins that influence lymphoid development and activity and bind the consensus DNA site GGA(A/T) through a unique winged helix-turn-helix motif known as the Ets domain. Spi-B and Spi-C (also known as SPIC) are closely related Ets family members which share a conserved divergent sequence within the Ets domain that enables their binding to non-canonical AGAA sites. Spi-C is a 248 amino acid protein that localizes to the nucleus and, like other Ets family members, binds DNA as a monomer and plays a role in transcriptional regulation. Addi- tionally, Spi-C is thought to control the development of red pulp macrophages, thereby contributing to iron homeostasis and red blood cell recycling. Human Spi-C shares 65 % amino acid identity with its mouse counterpart, suggesting a conserved role between species.

UniProt: Q8N5J4