SMNDC1 anticorps (full length)

N° du produit ABIN7879100

Cet anticorps Souris Monoclonal détecte spécifiquement SMNDC1 dans FACS et IF. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour SMNDC1 anticorps (full length) (ABIN7879100)

Antigène: SMNDC1 (Survival Motor Neuron Domain Containing 1 (SMNDC1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp SMNDC1 est non-conjugé

Application: Flow Cytometry (FACS), Immunofluorescence (IF)

Clone: PCRP-SMNDC1-1A9

Détail du produit anti-SMNDC1 anticorps

Épitope: full length

Fonction: SMNDC1 Antibody

Purification: Protein A/G affinity

Immunogène: Recombinant full-length human SMNDC1 protein was used as the immunogen for the SMNDC1 antibody.

Isotype: IgG2b

Information d'application

Indications d'application: Optimal dilution of the SMNDC1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the SMNDC1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur SMNDC1

Antigène: SMNDC1 (Survival Motor Neuron Domain Containing 1 (SMNDC1))

Autre désignation: SMNDC1

Sujet: SPF30 (survival of motor neuron-related-splicing factor 30), also known as SMNDC1 (survival motor neuron domain containing 1) or SMNR (SMN-related protein), is an essential splicing factor required for spliceosome assembly that belongs to the SMN family. It contains one Tudor domain with significant similarity to SMN (survival motor neuron) and is expressed in skeletal muscle, pancreas and heart, localizing to Cajal bodies and nuclear speckles. SPF30 plays an important role in spliceosome assembly and directly interacts with five U snRNPs. The loss of SPF30 causes spliceosome assembly to arrest at prespliceosomes (A complex). This supports a function for SPF30 in mediating the incorporation/recruitment of U4/U5/U6 tri-snRNP to the prespliceosome. In addition, the overexpression of SPF30 can lead to apoptosis.

UniProt: O75940