TARBP2 anticorps (full length)

N° du produit ABIN7879128

L’anticorps anti-TARBP2 Monoclonal Souris est utilisé pour la détection de TARBP2 dans des échantillons de Humain. Il a été validé pour WB, IF et FACS.

Aperçu rapide pour TARBP2 anticorps (full length) (ABIN7879128)

Antigène: TARBP2 (TAR (HIV-1) RNA Binding Protein 2 (TARBP2))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TARBP2 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)

Clone: PCRP-TARBP2-1E5

Détail du produit anti-TARBP2 anticorps

Épitope: full length

Fonction: TARBP2 Antibody

Purification: Protein A/G affinity

Immunogène: Recombinant full-length human TARBP2 protein was used as the immunogen for the TARBP2 antibody.

Isotype: IgG2a

Information d'application

Indications d'application: Optimal dilution of the TARBP2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the TARBP2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur TARBP2

Antigène: TARBP2 (TAR (HIV-1) RNA Binding Protein 2 (TARBP2))

Autre désignation: TARBP2

Sujet: TRBP2, also known as TARBP2 (trans-activation-responsive (HIV-1) RNA binding protein 2), TRBP1 or TRBP, is a nuclear protein that contains three DRBM (double-stranded RNA-binding) domains. TRBP binds between the bulge and the loop of the HIV-1 TAR RNA regulatory element and activates HIV-1 gene expression in synergy with the viral Tat protein. The third DRBM motif in the C-terminus of human TRBP2 can interact with and inhibit PKR activity, thereby increasing HIV-1 long terminal repeat (LTR) expression. In addition, TRBP2 functions as a component of a Dicer-containing complex and associates with the catalytic subunit of the RNA-induced silencing complex (RISC), namely eIF2C2. TRBP2 is essential for Dicer stability and the proper assembly of RISC. This suggests that TRBP2, in association with Dicer, plays an important role in the processing of miRNAs (microRNAs).

UniProt: Q15633

Pathways: Regulatory RNA Pathways, Ribonucleoprotein Complex Subunit Organization