Recombinant Thymidine Phosphorylase anticorps (full length)

N° du produit ABIN7879145

Cet anticorps Lapin Monoclonal détecte spécifiquement Thymidine Phosphorylase dans WB et IHC (p). Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour Recombinant Thymidine Phosphorylase anticorps (full length) (ABIN7879145)

Antigène: Thymidine Phosphorylase (TYMP)

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp Thymidine Phosphorylase est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Classe de qualité: Carrier-free

Clone: TYMP-2890R

Détail du produit anti-Thymidine Phosphorylase anticorps

Épitope: full length

Fonction: Recombinant Thymidine Phosphorylase Antibody / PD-ECGF (azide and preservative free)

Purification: Protein A affinity chromatography

Immunogène: Human recombinant full length protein was used as the immunogen for this recombinant Thymidine Phosphorylase antibody.

Isotype: IgG, kappa

Information d'application

Indications d'application: The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the recombinant Thymidine Phosphorylase antibody to be titered up or down for optimal performance.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: 4 °C,-20 °C

Stockage commentaire: Store the recombinant Thymidine Phosphorylase antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur Thymidine Phosphorylase

Antigène: Thymidine Phosphorylase (TYMP)

Autre désignation: Thymidine Phosphorylase

Sujet: Recognizes a 485 amino acid protein (55 kDa monomer / 110 kDa homodimer), identified as platelet-derived endothelial growth factor (PD-ECGF), also called Thymidine Phosphorylase (TP, Tymp) or Gliostatin. In the presence of inorganic orthophosphate, it catalyzes the reversible phospholytic cleavage of thymidine and deoxyuridine to their corresponding bases and 2-deoxyribose-1-phosphate. It is both chemotactic and mitogenic for endothelial cells and a non-heparin binding angiogenic factor present in platelets. Its enzymatic activity is crucial for angiogenic activity (metabolite is angiogenic). Higher levels of serum TP/PD-ECGF are observed in cancer patients. It is also involved in transformation of fluoropyrimidines, cytotoxic agents used in the treatment of a variety of malignancies, into active cytotoxic metabolites (e.g. 5 -deoxy-5-fluorouridine to 5-FU). High intra-cellular levels of TP/PD-ECGF are associated with increased chemosensitivity to such antimetabolites.

UniProt: P19971

Pathways: Signaling Events mediated by VEGFR1 and VEGFR2