Recombinant TOP1MT anticorps (full length)

N° du produit ABIN7879161

L’anticorps anti-TOP1MT Monoclonal Lapin est utilisé pour la détection de TOP1MT dans des échantillons de Humain. Il a été validé pour IHC (p).

Aperçu rapide pour Recombinant TOP1MT anticorps (full length) (ABIN7879161)

Antigène: TOP1MT (Topoisomerase (DNA) I, Mitochondrial (TOP1MT))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp TOP1MT est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: TPIMT-2R

Détail du produit anti-TOP1MT anticorps

Épitope: full length

Fonction: Recombinant TOP1MT Antibody

Purification: Protein A affinity chromatography

Immunogène: Recombinant full-length human protein was used as the immunogen for the recombinant TOP1MT antibody.

Isotype: IgG, kappa

Information d'application

Indications d'application: The stated application concentrations are suggested starting points. Titration of the recombinant TOP1MT antibody may be required due to differences in protocols and secondary/substrate sensitivity.

1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store the recombinant TOP1MT antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur TOP1MT

Antigène: TOP1MT (Topoisomerase (DNA) I, Mitochondrial (TOP1MT))

Autre désignation: TOP1MT

Sujet: DNA topoisomerases are nuclear enzymes that regulate the topological structure of DNA in eukaryotic cells by transiently breaking and rejoining DNA strands. Due to their roles in DNA replication, recombination, and transcription, DNA topoisomerases have been identified as targets of numerous anticancer drugs. Mitochondrial Topo I (DNA topoisomerase I, mitochondrial) is a 601 amino acid protein that primarily acts to relieve DNA strain that may occur during duplication of mitochondrial DNA. As a type IB topoisomerase, mitochondrial Topo I requires a divalent metal, either, calcium or magnesium, as well as an alkaline pH for optimal activity.

UniProt: Q969P6