Transgelin anticorps (full length)

N° du produit ABIN7879183

Cet anticorps anti-Transgelin Monoclonal Souris (Clone SPM606) (ABIN7879183) détecte spécifiquement Transgelin dans IHC (p). L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour Transgelin anticorps (full length) (ABIN7879183)

Antigène: Transgelin (TAGLN)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Transgelin est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: SPM606

Détail du produit anti-Transgelin anticorps

Épitope: full length

Fonction: Transgelin Antibody

Purification: Protein G affinity chromatography

Immunogène: Recombinant full-length human protein was used as the immunogen for the Transgelin antibody.

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal dilution of the Transgelin antibody should be determined by the researcher.

1. Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Tris with 1 mM EDTA, pH 9, for 10-20 min followed by cooling at RT for 20 min.
2. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Prediluted in 1X PBS, 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide, *For IHC use only*

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store the Transgelin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur Transgelin

Antigène: Transgelin (TAGLN)

Autre désignation: Transgelin

Sujet: This mAb recognizes a 22 kDa protein, identified as Transgelin, also designated SM22-alpha. It may cross-react with SM22-beta. Transgelin is expressed abundantly in smooth muscle cells. The human transgelin gene encodes a 201 amino acid protein that contains nuclear factor-binding motifs known to regulate transcription in smooth muscle. During embryogenesis, transgelin is expressed in smooth, cardiac and skeletal muscle, but is restricted during late fetal development and adulthood to all vascular and visceral smooth muscle cells and low levels of expression in heart. Transgelin is down regulated in several transformed cell lines, indicating that a reduction of transgelin expression may be an early indicator of the onset of transformation. Transgelin also binds Actin, causing Actin fibers to gel within minutes of binding. Binding of transgelin to Actin occurs at a ratio of 1:6 Actin monomers.

UniProt: Q01995