Tropomyosin anticorps (full length)

N° du produit ABIN7879209

L’anticorps anti-Tropomyosin Monoclonal Souris est utilisé pour la détection de Tropomyosin dans des échantillons de Humain. Il a été validé pour IHC (p).

Aperçu rapide pour Tropomyosin anticorps (full length) (ABIN7879209)

Antigène: Tropomyosin (TPM1) (Tropomyosin 1 (Alpha) (TPM1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Tropomyosin est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Classe de qualité: Carrier-free

Clone: TPM1-4510

Détail du produit anti-Tropomyosin anticorps

Épitope: full length

Fonction: Alpha Tropomyosin Antibody / Tropomyosin-1 / TPM1 (azide and preservative free)

Purification: Protein A/G affinity

Immunogène: Recombinant full-length protein was used as the immunogen for the Alpha Tropomyosin antibody.

Isotype: IgG1

Information d'application

Indications d'application: Optimal dilution of the Alpha Tropomyosin antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: -20 °C

Stockage commentaire: Aliquot the Alpha Tropomyosin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur Tropomyosin

Antigène: Tropomyosin (TPM1) (Tropomyosin 1 (Alpha) (TPM1))

Autre désignation: Alpha Tropomyosin

Sujet: Tropomyosins are a group of structural proteins. Tropomyosins are present in virtually all eukaryotic cells, both muscle and non-muscle, where they bind actin filaments and function to modulate Actin-myosin interaction and stabilize actin filament structure. Tropomyosin Alpha is encoded by the TPM1 gene, which maps to human chromosome 15q22.2 and undergoes alternative splicing to generate at least four isoforms, including skeletal muscle (isoform 1), smooth muscle (isoform 2), fibroblast/TM3 (isoform 3) and isoform 4. Tropomyosin b is encoded by the TPM2 gene, which maps to human chromosome 9p13.3 and undergoes alternative splicing to generate three isoforms, including skeletal muscle (isoform 1), non-muscle/fibroblast TM36/epithelial TMe1 (isoform 2) and non-muscle (isoform 3). Troponin I binds Tropomyosin at a specific region and the association of Tropomyosin-Troponin with actin filaments may increase the rigidity of actin filaments. Tropomyosin also interacts with caldesmon to regulate smooth muscle contraction.

UniProt: P04268

Pathways: Regulation of Actin Filament Polymerization