Tropomyosin anticorps (full length)

N° du produit ABIN7879210

Cet anticorps anti-Tropomyosin Monoclonal Souris (Clone TPM1-4510) (ABIN7879210) détecte spécifiquement Tropomyosin dans IHC (p). L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour Tropomyosin anticorps (full length) (ABIN7879210)

Antigène: Tropomyosin (TPM1) (Tropomyosin 1 (Alpha) (TPM1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Tropomyosin est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: TPM1-4510

Détail du produit anti-Tropomyosin anticorps

Épitope: full length

Fonction: Alpha Tropomyosin Antibody / Tropomyosin-1 / TPM1

Purification: Protein A/G affinity

Immunogène: Recombinant full-length protein was used as the immunogen for the Alpha Tropomyosin antibody.

Isotype: IgG1

Information d'application

Indications d'application: Optimal dilution of the Alpha Tropomyosin antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the Alpha Tropomyosin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur Tropomyosin

Antigène: Tropomyosin (TPM1) (Tropomyosin 1 (Alpha) (TPM1))

Autre désignation: Alpha Tropomyosin

Sujet: Tropomyosins are a group of structural proteins. Tropomyosins are present in virtually all eukaryotic cells, both muscle and non-muscle, where they bind actin filaments and function to modulate Actin-myosin interaction and stabilize actin filament structure. Tropomyosin Alpha is encoded by the TPM1 gene, which maps to human chromosome 15q22.2 and undergoes alternative splicing to generate at least four isoforms, including skeletal muscle (isoform 1), smooth muscle (isoform 2), fibroblast/TM3 (isoform 3) and isoform 4. Tropomyosin b is encoded by the TPM2 gene, which maps to human chromosome 9p13.3 and undergoes alternative splicing to generate three isoforms, including skeletal muscle (isoform 1), non-muscle/fibroblast TM36/epithelial TMe1 (isoform 2) and non-muscle (isoform 3). Troponin I binds Tropomyosin at a specific region and the association of Tropomyosin-Troponin with actin filaments may increase the rigidity of actin filaments. Tropomyosin also interacts with caldesmon to regulate smooth muscle contraction.

UniProt: P04268

Pathways: Regulation of Actin Filament Polymerization