Tyrosinase-Related Protein 1 anticorps (full length)

N° du produit ABIN7879274

Cet anticorps Souris Monoclonal détecte spécifiquement Tyrosinase-Related Protein 1 dans IHC (p). Il présente une réactivité avec des échantillons de Humain et Souris.

Aperçu rapide pour Tyrosinase-Related Protein 1 anticorps (full length) (ABIN7879274)

Antigène: Tyrosinase-Related Protein 1 (TYRP1)

Reactivité: Humain, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Tyrosinase-Related Protein 1 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: SPM611

Détail du produit anti-Tyrosinase-Related Protein 1 anticorps

Épitope: full length

Fonction: TRP1 Antibody / Tyrosinase-Related Protein-1 Antibody / TYRP1

Purification: Protein G affinity chromatography

Immunogène: Recombinant full-length human protein was used as the immunogen for the TRP1 antibody.

Isotype: IgG2a, kappa

Information d'application

Indications d'application: Optimal dilution of the TRP1 antibody should be determined by the researcher.

1. Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Tris with 1 mM EDTA, pH 9, for 10-20 min followed by cooling at RT for 20 min.
2. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Prediluted in 1X PBS, 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide, *For IHC use only*

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store the TRP1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur Tyrosinase-Related Protein 1

Antigène: Tyrosinase-Related Protein 1 (TYRP1)

Autre désignation: TRP1 / Tyrosinase-Related Protein-1

Sujet: It reacts with a 75 kDa melanocyte-specific gene product, identified as Tyrosinase-related protein-1 (TRP-1). It is involved in melanin synthesis. TRP1 is present on the melanosomal membranes of melanoma, normal melanocytes and nevi. Recent evidence suggests that TRP-1 is involved in maintaining stability of tyrosinase protein and modulating its catalytic activity. TRP-1 is also involved in maintenance of melanosome ultrastructure and affects melanocyte proliferation and cell death.

UniProt: P17643