WTAP anticorps (full length)

N° du produit ABIN7879325

Cet anticorps Souris Monoclonal détecte spécifiquement WTAP dans IHC (p) et FACS. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour WTAP anticorps (full length) (ABIN7879325)

Antigène: WTAP (Wilms Tumor 1 Associated Protein (WTAP))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp WTAP est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Classe de qualité: Carrier-free

Clone: PCRP-WTAP-1A4

Détail du produit anti-WTAP anticorps

Épitope: full length

Fonction: WT1-associated protein Antibody / WTAP (azide and preservative free)

Purification: Protein A/G affinity

Immunogène: Recombinant full-length human protein was used as the immunogen for the WT1-associated protein antibody.

Isotype: IgG2b, kappa

Information d'application

Indications d'application: Optimal dilution of the WT1-associated protein antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: -20 °C

Stockage commentaire: Aliquot the WT1-associated protein antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur WTAP

Antigène: WTAP (Wilms Tumor 1 Associated Protein (WTAP))

Autre désignation: WT1-associated protein

Sujet: Wilms tumor (WT) is an embryonal malignancy of the kidney that affects 1 in 10,000 infants and is observed in both sporadic and inherited forms. The Wilms tumor protein (WT1) binds the DNA sequence GCGGGGGCG, a recognition element common to the early growth response (Egr) family of Zn2+ finger transcriptional activators, and functions as a transcriptional repressor. WTAP (wilms tumor 1-associating protein) is a ubiquitously expressed nuclear protein that interacts with WT1 and may be involved in regulating mRNA splicing. WTAP is found in nuclear speckles, where it regulates the G2/M cell cycle transition by binding to the 3' UTR of cyclin A2, thus enhancing its stability. Additionally, WTAP inhibits expression of WT1 target genes and is able to impair the ability of WT1 to bind DNA. Two isoforms of WTAP exist due to alternative splicing events.

UniProt: Q15007