Recombinant Histone H2A anticorps (H2AK118me1)

N° du produit ABIN7879413

L’anticorps anti-Histone H2A Monoclonal Lapin est utilisé pour la détection de Histone H2A dans des échantillons de Humain, Souris et Rat. Il a été validé pour WB, IHC, IF et ICC.

Aperçu rapide pour Recombinant Histone H2A anticorps (H2AK118me1) (ABIN7879413)

Antigène: Histone H2A

Type d'anticorp: Recombinant Antibody

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp Histone H2A est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Clone: 31H85

Détail du produit anti-Histone H2A anticorps

Épitope: H2AK118me1

Fonction: Histone H2A (mono methyl K118) Antibody / HIST1H2AB

Purification: Affinity chromatography

Immunogène: A synthesized peptide derived from human Histone H2A (mono methyl K118) was used as the immunogen for the Histone H2A (mono methyl K118) antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the Histone H2A (mono methyl K118) antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store the Histone H2A (mono methyl K118) antibody at -20oC.

Détails sur Histone H2A

Antigène: Histone H2A

Sujet: Histone H2A (mono methyl K118) antibody detects Histone H2A monomethylated at lysine 118, encoded by the HIST1H2AB gene. Histone H2A is a core nucleosomal protein that forms the nucleosome octamer with histones H2B, H3, and H4. Post translational modifications of histone H2A regulate chromatin structure and gene expression. Monomethylation at lysine 118 represents an important epigenetic mark associated with transcriptional regulation and genome stability. Histone H2A (mono methyl K118) antibody provides researchers with a powerful tool for epigenetic and chromatin research.

Histone modifications such as acetylation, methylation, and phosphorylation function as signals that recruit or repel regulatory proteins. Research using Histone H2A (mono methyl K118) antibody has demonstrated that lysine 118 monomethylation influences transcriptional elongation and DNA damage repair. The modification occurs in the globular domain of histone H2A, suggesting a structural impact on nucleosome stability and interactions with regulatory proteins.

In development, lysine 118 methylation has been linked to regulation of gene expression programs during differentiation. Studies with Histone H2A (mono methyl K118) antibody have shown that abnormal regulation of this mark can disrupt normal transcriptional control, leading to developmental abnormalities. The modification is also dynamically regulated in response to cellular stress, indicating its importance in adaptation and signaling.

Dysregulation of histone H2A methylation, including lysine 118, has been implicated in cancer. Research using Histone H2A (mono methyl K118) antibody has revealed that changes in this modification alter chromatin accessibility and influence oncogene or tumor suppressor gene expression. Because epigenetic states are reversible, histone modifications such as H2A K118 methylation represent potential therapeutic targets in oncology.

Histone H2A (mono methyl K118) antibody is applied in chromatin immunoprecipitation, western blotting, and immunofluorescence. Chromatin immunoprecipitation maps genome wide distribution of the modification, western blotting distinguishes specific modification states, and immunofluorescence reveals nuclear distribution patterns. These applications make Histone H2A (mono methyl K118) antibody essential for chromatin biology research.

By supplying validated Histone H2A (mono methyl K118) antibody reagents, NSJ Bioreagents supports research into epigenetic regulation, transcription, and cancer. Detection of Histone H2A monomethylated at lysine 118 provides insight into chromatin control mechanisms that underlie development and disease.

UniProt: P04908