ALDOC anticorps (N-Term)

N° du produit ABIN7879558

Cet anticorps anti-ALDOC Polyclonal Lapin (ABIN7879558) détecte spécifiquement ALDOC dans WB et IHC. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour ALDOC anticorps (N-Term) (ABIN7879558)

Antigène: ALDOC (Aldolase C, Fructose-Bisphosphate (ALDOC))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ALDOC est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-ALDOC anticorps

Épitope: N-Term

Fonction: ALDOC Antibody / Aldolase C

Purification: Immunogen affinity purified

Immunogène: A synthetic peptide corresponding to a sequence at the N-terminus of human Aldolase C/ALDOC was used as the immunogen for the ALDOC antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the ALDOC antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the ALDOC antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur ALDOC

Antigène: ALDOC (Aldolase C, Fructose-Bisphosphate (ALDOC))

Autre désignation: ALDOC

Sujet: ALDOC antibody detects Aldolase C, a glycolytic enzyme involved in the reversible cleavage of fructose-1,6-bisphosphate into dihydroxyacetone phosphate and glyceraldehyde-3-phosphate. Encoded by the ALDOC gene on chromosome 17q11.2, this protein is one of three aldolase isoenzymes (A, B, and C) expressed in a tissue-specific manner. Aldolase C is predominantly found in the brain and other neural tissues, where it supports both glycolytic energy metabolism and neuronal development.

Structurally, Aldolase C functions as a homotetramer with catalytic lysine residues that form Schiff bases with its substrate. It shares high sequence identity with Aldolase A (muscle type) and B (liver type) but exhibits unique kinetic properties suited for neuronal metabolism. In neurons and glial cells, Aldolase C contributes to glucose utilization, energy coupling, and maintenance of synaptic function. It also interacts with cytoskeletal proteins, suggesting roles beyond metabolism, including regulation of actin organization and cell morphology.

The ALDOC antibody is widely used in neuroscience, metabolism, and cell biology research to study glycolytic regulation and neural differentiation. Western blot analysis identifies a 39 kilodalton band corresponding to Aldolase C, while immunohistochemistry reveals strong cytoplasmic staining in Purkinje cells and astrocytes. This antibody supports investigation of metabolic compartmentalization and energy flux in the central nervous system.

Altered expression of Aldolase C has been observed in neurodegenerative diseases and gliomas, where metabolic reprogramming contributes to pathogenesis. Beyond the brain, ALDOC expression in epithelial and endocrine tissues suggests additional roles in energy balance and biosynthesis. The ALDOC antibody provides a reliable reagent for analyzing glycolytic enzyme distribution and function. NSJ Bioreagents offers this antibody validated for its applications, ensuring high specificity and reproducibility for metabolic and neurobiological studies.

UniProt: P09972