Annexin A2 anticorps (N-Term)

N° du produit ABIN7879560

L’anticorps anti-Annexin A2 Polyclonal Lapin est utilisé pour la détection de Annexin A2 dans des échantillons de Humain, Souris et Rat. Il a été validé pour WB et FACS.

Aperçu rapide pour Annexin A2 anticorps (N-Term) (ABIN7879560)

Antigène: Annexin A2 (ANXA2)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Annexin A2 est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS)

Détail du produit anti-Annexin A2 anticorps

Épitope: N-Term

Fonction: ANXA2 Antibody / Annexin A2

Purification: Immunogen affinity purified

Immunogène: A synthetic peptide corresponding to a sequence at the N-terminus of human ANXA2 was used as the immunogen for the ANXA2 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the ANXA2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the ANXA2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur Annexin A2

Antigène: Annexin A2 (ANXA2)

Autre désignation: ANXA2

Sujet: ANXA2 antibody detects Annexin A2, a calcium-dependent phospholipid-binding protein involved in membrane organization, cytoskeletal interactions, and fibrinolysis. Encoded by the ANXA2 gene on chromosome 15q26.1, this multifunctional protein participates in membrane trafficking, endocytosis, cell-cell adhesion, and extracellular matrix remodeling. Annexin A2 also acts as a cell surface receptor for tissue plasminogen activator (tPA) and plasminogen, facilitating localized fibrin degradation and vascular repair.

Structurally, Annexin A2 is a 339-amino-acid protein of approximately 39 kilodaltons containing four annexin repeats that mediate calcium-dependent phospholipid binding and a unique N-terminal domain that interacts with S100A10 (p11) to form a heterotetrameric complex. This complex localizes to the plasma membrane, cytoskeleton, and endosomal compartments, where it modulates vesicle fusion, cytoskeletal anchoring, and membrane curvature. Annexin A2 is expressed in endothelial, epithelial, and tumor cells, as well as macrophages and neurons.

The ANXA2 antibody is widely used in cell biology, vascular biology, and cancer research to study membrane organization, signal transduction, and fibrinolytic regulation. Western blot analysis detects a 39 kilodalton band corresponding to Annexin A2, while immunofluorescence shows cytoplasmic, membrane, and perinuclear localization. This antibody provides a powerful reagent for investigating calcium-dependent membrane remodeling and extracellular proteolytic activity.

Functionally, Annexin A2 regulates actin cytoskeleton rearrangement and vesicle trafficking, influencing endocytosis, exocytosis, and cell motility. At the cell surface, it promotes plasmin generation, contributing to fibrin degradation, angiogenesis, and tumor invasion. Dysregulation of ANXA2 expression is associated with cancer progression, thrombosis, and inflammatory disease. The ANXA2 antibody supports detailed studies of its role in cellular dynamics, extracellular matrix remodeling, and vascular homeostasis. NSJ Bioreagents validates this antibody for its applications, ensuring precise detection in studies of cytoskeletal and membrane biology.

UniProt: P07355

Pathways: S100 Proteins