Recombinant PKD2 anticorps (pSer876)

N° du produit ABIN7879775

Cet anticorps Lapin Monoclonal détecte spécifiquement PKD2 dans WB. Il présente une réactivité avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour Recombinant PKD2 anticorps (pSer876) (ABIN7879775)

Antigène: PKD2 (Protein Kinase D2 (PKD2))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp PKD2 est non-conjugé

Application: Western Blotting (WB)

Clone: 32P58

Détail du produit anti-PKD2 anticorps

Épitope: pSer876

Fonction: Phospho-Protein Kinase D2 (Ser876) Antibody / PRKD2

Purification: Affinity chromatography

Immunogène: A synthesized peptide derived from human Phospho-Protein Kinase D2 (S876) was used as the immunogen for the Phospho-Protein Kinase D2 (Ser876) antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the Phospho-Protein Kinase D2 (Ser876) antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store the Phospho-Protein Kinase D2 (Ser876) antibody at -20oC.

Détails sur PKD2

Antigène: PKD2 (Protein Kinase D2 (PKD2))

Autre désignation: Protein Kinase D2

Sujet: Phospho-Protein kinase D2 (Ser876) antibody detects Protein kinase D2 phosphorylated at serine 876, encoded by the PRKD2 gene. Protein kinase D2 is a member of the protein kinase D family of serine threonine kinases that integrate signals from diacylglycerol, protein kinase C, and G protein coupled receptors. Phosphorylation at serine 876 is a critical regulatory event required for full catalytic activity. Phospho-Protein kinase D2 (Ser876) antibody provides researchers with a precise tool to study PRKD2 signaling in cell proliferation, migration, and inflammation.

Protein kinase D2 plays a central role in diverse cellular pathways, including vesicle trafficking, oxidative stress responses, and cytoskeletal remodeling. Studies with Phospho-Protein kinase D2 (Ser876) antibody have shown that phosphorylation at serine 876 occurs within the activation loop of the kinase domain, stabilizing active conformations and promoting downstream signaling. Activation of PRKD2 influences nuclear factor kappa B activity, gene expression, and secretion of cytokines. This modification thus represents a key regulatory switch linking extracellular signals to transcriptional responses.

PRKD2 has been implicated in oncogenesis, cardiovascular disease, and immune regulation. Research using Phospho-Protein kinase D2 (Ser876) antibody has revealed that hyperactivation of PRKD2 promotes tumor growth, angiogenesis, and metastasis by stimulating survival and motility pathways. In the cardiovascular system, phosphorylation of PRKD2 influences contraction, vascular permeability, and stress responses. Its role in immune signaling involves regulation of T cell receptor pathways and cytokine secretion. The breadth of these functions underscores the importance of monitoring phosphorylation status.

Beyond physiological roles, PRKD2 has become a potential therapeutic target. Small molecule inhibitors that block PRKD activation have been investigated in preclinical cancer and inflammatory models. Phospho-Protein kinase D2 (Ser876) antibody is a valuable tool in assessing drug effects by specifically detecting activation state. Such reagents allow researchers to dissect how therapies modulate phosphorylation dependent PRKD2 signaling and how this impacts cellular outcomes.

Phospho-Protein kinase D2 (Ser876) antibody is applied in western blotting, immunohistochemistry, and immunofluorescence. Western blotting distinguishes phosphorylated from total PRKD2, while immunohistochemistry reveals activation patterns in tissue samples. Immunofluorescence demonstrates dynamic localization changes upon stimulation, providing insight into subcellular distribution of active kinase. These applications make the antibody essential for signaling research.

By supplying validated Phospho-Protein kinase D2 (Ser876) antibody reagents, NSJ Bioreagents supports studies of kinase regulation, cancer, and cardiovascular disease. Detection of phosphorylation at serine 876 provides insight into mechanisms of signal transduction and their dysregulation in pathology.

UniProt: Q9BZL6

Pathways: cAMP Metabolic Process, Maintenance of Protein Location, Negative Regulation of Transporter Activity