Recombinant Caveolin-1 anticorps (pTyr14)

N° du produit ABIN7879827

L’anticorps anti-Caveolin-1 Monoclonal Lapin est utilisé pour la détection de Caveolin-1 dans des échantillons de Humain. Il a été validé pour WB.

Aperçu rapide pour Recombinant Caveolin-1 anticorps (pTyr14) (ABIN7879827)

Antigène: Caveolin-1 (CAV1) (Caveolin 1, Caveolae Protein, 22kDa (CAV1))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp Caveolin-1 est non-conjugé

Application: Western Blotting (WB)

Clone: 32C49

Détail du produit anti-Caveolin-1 anticorps

Épitope: pTyr14

Fonction: Phospho-Caveolin 1 (Tyr14) Antibody / CAV1

Purification: Affinity chromatography

Immunogène: A synthesized peptide derived from human Phospho-Caveolin-1 (Y14) was used as the immunogen for the Phospho-Caveolin 1 (Tyr14) antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the Phospho-Caveolin 1 (Tyr14) antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store the Phospho-Caveolin 1 (Tyr14) antibody at -20oC.

Détails sur Caveolin-1

Antigène: Caveolin-1 (CAV1) (Caveolin 1, Caveolae Protein, 22kDa (CAV1))

Autre désignation: Caveolin 1

Sujet: Phospho-Caveolin 1 (Tyr14) antibody detects Caveolin 1 phosphorylated at tyrosine 14, encoded by the CAV1 gene. Caveolin 1 is an integral membrane protein and principal component of caveolae, small invaginations in the plasma membrane involved in endocytosis, cholesterol homeostasis, and signal transduction. Phosphorylation at tyrosine 14 is a key regulatory modification that alters Caveolin 1 function and interactions with signaling molecules. Phospho-Caveolin 1 (Tyr14) antibody provides researchers with a powerful tool for investigating membrane dynamics and signaling pathways regulated by caveolae.

Caveolin 1 acts as a scaffolding protein that organizes signaling complexes at the plasma membrane. Research using Phospho-Caveolin 1 (Tyr14) antibody has demonstrated that phosphorylation at tyrosine 14 is mediated primarily by Src family kinases in response to growth factors, mechanical stress, or cellular adhesion events. This modification induces conformational changes that modulate protein interactions and influence downstream signaling. By altering binding partners, phosphorylation at Tyr14 affects processes such as focal adhesion turnover, cell migration, and proliferation.

Studies with Phospho-Caveolin 1 (Tyr14) antibody have shown that this modification regulates integrin signaling and cytoskeletal dynamics. Phosphorylated Caveolin 1 promotes disassembly of focal adhesions, allowing cells to migrate during wound healing, angiogenesis, and cancer metastasis. It also participates in mechanotransduction, enabling cells to sense and respond to changes in extracellular matrix stiffness or fluid shear stress. These findings highlight the versatility of Caveolin 1 phosphorylation as a regulatory switch in cell biology.

Dysregulation of Caveolin 1 phosphorylation has been linked to multiple diseases. Research using Phospho-Caveolin 1 (Tyr14) antibody has revealed altered phosphorylation in cancer, where excessive modification promotes tumor cell invasion and metastasis. In cardiovascular disease, abnormal Caveolin 1 phosphorylation disrupts endothelial function and contributes to vascular pathology. In pulmonary fibrosis, changes in Caveolin 1 phosphorylation status affect fibroblast activation and extracellular matrix remodeling. These diverse roles emphasize its broad clinical relevance.

Phospho-Caveolin 1 (Tyr14) antibody is widely used in western blotting, immunohistochemistry, and immunofluorescence. Western blotting distinguishes phosphorylated Caveolin 1 from its unmodified form, immunohistochemistry identifies activated signaling domains in tissues, and immunofluorescence visualizes phosphorylated Caveolin 1 within caveolae at the plasma membrane. These applications make the antibody indispensable for cell signaling and membrane biology research.

By providing validated Phospho-Caveolin 1 (Tyr14) antibody reagents, NSJ Bioreagents supports studies into membrane signaling, cytoskeletal regulation, and disease processes. Detection of Caveolin 1 phosphorylation at tyrosine 14 offers a highly specific marker of caveolae mediated signaling activity.

UniProt: Q03135

Pathways: Maintenance of Protein Location, Signaling Events mediated by VEGFR1 and VEGFR2, Negative Regulation of Transporter Activity, VEGFR1 Specific Signals