Alkaline Phosphatase anticorps

N° du produit ABIN7879949

Cet anticorps Souris Monoclonal détecte spécifiquement Alkaline Phosphatase dans IHC (p). Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour Alkaline Phosphatase anticorps (ABIN7879949)

Antigène: Alkaline Phosphatase (ALP)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Alkaline Phosphatase est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Classe de qualité: Carrier-free

Clone: SPM372

Détail du produit anti-Alkaline Phosphatase anticorps

Fonction: Alkaline Phosphatase Antibody / ALPL (azide and preservative free)

Purification: Protein G affinity chromatography

Immunogène: Bovine intestinal alkaline phosphatase was used as the immunogen for the Alkaline Phosphatase antibody.

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal dilution of the Alkaline Phosphatase antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: 4 °C,-20 °C

Stockage commentaire: Store the Alkaline Phosphatase antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur Alkaline Phosphatase

Antigène: Alkaline Phosphatase (ALP)

Autre désignation: Alkaline Phosphatase

Sujet: There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization, however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypo-phosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants, which encode the same protein, have been identified for this gene.

UniProt: P09923