Fetuin A anticorps

N° du produit ABIN7879956

L’anticorps anti-Fetuin A Monoclonal Souris est utilisé pour la détection de Fetuin A dans des échantillons de Humain. Il a été validé pour IHC (p).

Aperçu rapide pour Fetuin A anticorps (ABIN7879956)

Antigène: Fetuin A (AHSG) (alpha-2-HS-Glycoprotein (AHSG))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Fetuin A est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: AHSG-3748

Détail du produit anti-Fetuin A anticorps

Fonction: Fetuin-A Antibody / AHSG

Purification: Protein A/G affinity

Immunogène: A recombinant protein fragment was used as the immunogen for the Fetuin-A antibody.

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal dilution of the Fetuin-A antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the Fetuin-A antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur Fetuin A

Antigène: Fetuin A (AHSG) (alpha-2-HS-Glycoprotein (AHSG))

Autre désignation: Fetuin-A

Sujet: Fetuin (also designated 2-HS-glycoprotein) is a secreted plasma protein that is expressed in hepatocytes, monocyte/macrophages and in bone and is downregulated during injury and inflammation. Fetuin preferentially binds to and carries calcium and barium ions in the blood, where it is thought to mediate serum calcium homeostasis and mineralization, and to potentially participate in the transport of bioactive molecules. Additionally, fetuin has been shown to function as an acute phase anti-inflammatory mediator that is critical to regulating the innate immune response following tissue injury. During inflammation, circulating fetuin levels substantially decrease as fetuin becomes associated with the membranes of macrophages. This membrane associated form of fetuin acts as an opsonic participant by potentiating the entry of cationic small molecules into the activated macro-phage, which in turn facilitates macrophage-deactivating mechanisms. Biologically active fetuin is derived from a precursor protein that is cleaved at the aminoterminus to generate two chains held together by a single disulfide bond.

UniProt: P02765