BUB1B anticorps

N° du produit ABIN7880116

Cet anticorps anti-BUB1B Monoclonal Lapin (Clone ABFG-2) (ABIN7880116) détecte spécifiquement BUB1B dans WB. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour BUB1B anticorps (ABIN7880116)

Antigène: BUB1B (Budding Uninhibited By Benzimidazoles 1 Homolog beta (Yeast) (BUB1B))

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp BUB1B est non-conjugé

Application: Western Blotting (WB)

Clone: ABFG-2

Détail du produit anti-BUB1B anticorps

Fonction: BUB1B Antibody

Purification: Affinity purified

Immunogène: A synthetic peptide specific to human BUB1B was used as the immunogen for the BUB1B antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the BUB1B antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Antibody in PBS with 0.02 % sodium azide, 50 % glycerol and 0.4-0.5 mg/mL BSA

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store the BUB1B antibody at -20oC.

Détails sur BUB1B

Antigène: BUB1B (Budding Uninhibited By Benzimidazoles 1 Homolog beta (Yeast) (BUB1B))

Autre désignation: BUB1B

Sujet: Mitotic checkpoint serine/threonine-protein kinase BUB1 beta,' also called BubR1, is an essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression. [UniProt]

UniProt: O60566