Recombinant CABP1 anticorps

N° du produit ABIN7880136

L’anticorps anti-CABP1 Monoclonal Lapin est utilisé pour la détection de CABP1 dans des échantillons de Humain et Souris. Il a été validé pour WB, ICC et IF.

Aperçu rapide pour Recombinant CABP1 anticorps (ABIN7880136)

Antigène: CABP1 (Calcium Binding Protein 1 (CABP1))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp CABP1 est non-conjugé

Application: Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)

Clone: 31C60

Détail du produit anti-CABP1 anticorps

Fonction: CABP1 Antibody / Calcium binding protein 1

Purification: Affinity-chromatography

Immunogène: A synthesized peptide derived from human CABP was used as the immunogen for the CABP1 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the CABP1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store the CABP1 antibody at -20oC.

Détails sur CABP1

Antigène: CABP1 (Calcium Binding Protein 1 (CABP1))

Autre désignation: CABP1

Sujet: CABP1 antibody detects calcium binding protein 1, a neuronal calcium binding protein encoded by the CABP1 gene. CABP1 belongs to the calmodulin like protein family and contains EF hand domains that sense calcium signals. It regulates calcium channels, neurotransmitter release, and synaptic plasticity. CABP1 is predominantly expressed in brain and retina, where it modulates signaling events essential for neuronal communication and vision.

CABP1 antibody is widely used in neuroscience and sensory biology research. CABP1 interacts with L type calcium channels and inositol 1,4,5 triphosphate receptors, tuning calcium signaling in neurons. It plays roles in learning, memory, and synaptic adaptation. In the retina, CABP1 modulates photoreceptor signaling and contributes to visual processing. By detecting CABP1, researchers can evaluate how neuronal calcium sensors shape cellular signaling.

In western blot assays, CABP1 antibody detects protein bands corresponding to expected isoforms in neural tissue. Immunohistochemistry highlights expression in hippocampus and retina, while immunofluorescence reveals subcellular localization at synapses and dendrites. These methods support detailed analysis of calcium binding proteins in neurons.

Altered CABP1 expression has been linked to neurological disorders including schizophrenia and epilepsy, where calcium signaling is disrupted. CABP1 also influences neuronal excitability and response to stress, suggesting broader roles in neuroprotection. By applying CABP1 antibody, scientists can investigate how calcium sensors contribute to brain function and disease mechanisms.

CABP1 antibody from NSJ Bioreagents offers strong specificity for detecting calcium binding protein 1 across tissues. Its reliable performance across multiple applications ensures accurate results, supporting research into calcium regulation in neural signaling and vision.

UniProt: Q9NZU7

Pathways: Synaptic Membrane, Negative Regulation of Transporter Activity