Recombinant CD163L1 anticorps

N° du produit ABIN7880238

L’anticorps anti-CD163L1 Monoclonal Lapin est utilisé pour la détection de CD163L1 dans des échantillons de Humain. Il a été validé pour IHC.

Aperçu rapide pour Recombinant CD163L1 anticorps (ABIN7880238)

Antigène: CD163L1 (CD163 Molecule-Like 1 (CD163L1))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp CD163L1 est non-conjugé

Application: Immunohistochemistry (IHC)

Clone: 31C59

Détail du produit anti-CD163L1 anticorps

Fonction: CD163L1 Antibody / CD163 like 1 / CD163b

Purification: Affinity chromatography

Immunogène: A synthesized peptide derived from human CD163L1 was used as the immunogen for the CD163L1 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the CD163L1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store the CD163L1 antibody at -20oC.

Détails sur CD163L1

Antigène: CD163L1 (CD163 Molecule-Like 1 (CD163L1))

Autre désignation: CD163L1

Sujet: CD163L1 antibody detects CD163 like 1 protein, also called CD163b, encoded by the CD163L1 gene. CD163 like 1 is a scavenger receptor expressed on subsets of monocytes and macrophages, structurally related to CD163 but with distinct ligand binding and immune functions. CD163L1 antibody provides researchers with a valuable tool to study macrophage biology, innate immunity, and inflammatory disease.

CD163 like 1 is a member of the scavenger receptor cysteine-rich family and localizes to the plasma membrane of immune cells. Research using CD163L1 antibody has shown that this receptor binds hemoglobin haptoglobin complexes and other ligands, contributing to clearance of hemoglobin and modulation of inflammation. Unlike CD163, CD163L1 expression is restricted to specific immune cell subsets, suggesting specialized functions in innate defense.

In immune regulation, CD163L1 influences cytokine responses and macrophage polarization. Studies with CD163L1 antibody have demonstrated that its engagement alters production of pro- and anti-inflammatory mediators, shaping immune responses during infection and tissue repair. Dysregulation of CD163L1 expression has been associated with chronic inflammation and autoimmune disorders.

Beyond immunity, CD163L1 has been implicated in cardiovascular and metabolic diseases. Research using CD163L1 antibody has revealed associations with atherosclerosis, where scavenger receptor activity influences lipid uptake and foam cell formation. In metabolic disease, altered expression may contribute to chronic low-grade inflammation in obesity and diabetes. These findings expand the role of CD163L1 beyond classical scavenger functions to systemic disease processes.

CD163L1 antibody is applied in western blotting, immunohistochemistry, and flow cytometry. Western blotting confirms protein size, immunohistochemistry shows tissue localization, and flow cytometry quantifies expression on immune subsets. These methods make CD163L1 antibody useful in immunology and pathology research.

By providing validated CD163L1 antibody reagents, NSJ Bioreagents supports research into macrophage biology, innate immunity, and inflammatory disease. Detection of CD163 like 1 protein enables researchers to examine how scavenger receptors shape immune responses and disease progression.

UniProt: Q9NR16